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nicoti·namide n-methyl·trans·ferase
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- In enzymology, a nicotinamide N-methyltransferase (NNMT) (EC 2.1.1.1) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + nicotinamide ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + 1-methylnicotinamide.Thus, the two substrates of this enzyme are S-adenosyl methionine and nicotinamide, whereas its two products are S-adenosylhomocysteine and 1-methylnicotinamide. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:nicotinamide N-methyltransferase. This enzyme is also called nicotinamide methyltransferase.
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