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What rhymes with eif-2 kinase?
eif-2 ki·nase
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- eIF-2 is a kinase enzyme that phosphorylates eIF-2. There are four forms in mammals: ⁕EIF2AK1: heme-regulated inhibitor kinase ⁕EIF2AK2: the double-stranded RNA-dependent kinase ⁕EIF2AK3: PEK/PERK ⁕EIF2AK4: GCN2 These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized mechanisms for down-regulating protein synthesis in eukaryotes in response to various cellular stress response's.
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