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cd40
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- Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. In addition it is expressed by various non- hematopoietic cells; activated CD4+ T cells primarily exhibit its ligand CD154, antigen-presenting cells including dendritic cells (DCs), B cells, macrophages, classical and non-classical monocytes, on a variety of non-immune cells including platelets and endothelial cells, and on several types of tumor cells.Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency.
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"cd40 Rhymes." Rhymes.com. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.rhymes.com/rhyme/cd40>.
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