- An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
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"11-beta-hydroxysteroid dehydrogenase type 2." Rhymes.net. STANDS4 LLC, 2016. Web. 28 Jul 2016. <http://www.rhymes.net/rhyme/11-beta-hydroxysteroid%20dehydrogenase%20type%202>.